Fat feeding and cholesterol absorption

Effects of alcohol and cholesterol feeding on lipoprotein metabolism and cholesterol absorption in rabbits.

Alcohol fed to rabbits in a liquid formula at 30% of calories increased plasma cholesterol by 36% in the absence of dietary cholesterol and by 40% in the presence of a 0.5% cholesterol diet. The increase was caused almost entirely by VLDL, IDL, and LDL. Cholesterol feeding decreased the fractional catabolic rate for VLDL and LDL apoprotein by 80% and 57%, respectively, and increased the product...

Mechanism of cholesterol absorption. II. Changes in free and esterified cholesterol pools of mucosa after feeding cholesterol-4-C14.

In a previous study (1) it was shown that the transfer of fed cholesterol-4-Cl4 to the lymph was very rapid; the peak of absorption occurred in 6 to 8 hours, but cholesterol-4-Cl4 continued to appear in lymph up to 48 hours. There was considerable endogenous dilution of the fed cholesterol-4-Cl4 during its passage from the lumen to the lymph; this dilution was smallest during the period of rapi...

Composition and concentration of lymph and serum lipoproteins during fat and cholesterol absorption in the dog.

The term chylomicron was introduced by Gage in 1920 (1) to refer to particles, mostly 0.5 to 1 p in diameter and visible with the high power, dark-field microscope, found in the intestinal lacteals and plasma during the absorption of fats. A detailed report on the nature of these particles was published by Gage and Fish in 1924 (2). Chylomicrons, as defined above, have not as yet been isolated ...

Effects of feeding cholic acid and chenodeoxycholic acid on cholesterol absorption and hepatic secretion

Chenodeoxycholic acid (CDCA), in contrast to cholic acid (CA), reduces cholesterol saturation of bile. The mechanisms for these differences were the object of this study. Investigations were carried out in nine white men; three nonobese subjects and one obese subject were fed a weight-maintenance diet, and five obese patients had a reduced caloric intake for weight reduction. They were given a ...

Fatty Acid Esterification and Chylomicron Formation during Fat Absorption. 1. Triglycerides and Cholesterol Esters.